Blog
Sildenafil vs Vardenafil: Which Works Faster for ED Treatment in Australia?
Oct
Key Takeaways
- Sildenafil (Cenforce) and Vardenafil (Valif) both treat erectile dysfunction (ED) by increasing blood flow.
- Vardenafil typically works faster but lasts slightly shorter.
- Sildenafil is more affordable and widely available across Australia.
- Both are safe when prescribed correctly and used responsibly.
- Lifestyle, dosage, and health conditions affect how well each works.
Introduction
When it comes to treating erectile dysfunction (ED), two names often stand out — Sildenafil and Vardenafil. Both belong to the PDE5 inhibitor family, working through a similar mechanism but offering slightly different experiences.
If you’re deciding between Cenforce (Sildenafil) and Valif (Vardenafil), this guide explains which works faster, how long each lasts, and what factors influence their effectiveness for Australian men.
What Is Sildenafil (Cenforce)?
Sildenafil citrate is the active ingredient in Cenforce, one of the most trusted alternatives to Viagra. It relaxes blood vessels and boosts circulation to help men achieve and maintain an erection naturally.
- Onset: 30–60 minutes
- Duration: 4–6 hours
- Available strengths: 50mg, 100mg, 200mg
Its effectiveness depends on timing, meal type, and dosage. You can read more in our full guide: How Long Does Sildenafil Last?
According to Healthline’s review of ED medications, Sildenafil remains one of the most researched and reliable PDE5 inhibitors available worldwide.
What Is Vardenafil (Valif)?
Vardenafil, marketed as Valif, is another PDE5 inhibitor similar to Sildenafil but known for its slightly faster onset and higher potency per milligram.
- Onset: 20–45 minutes
- Duration: 4–5 hours
- Available strength: 20mg
Vardenafil is often recommended for men who prefer a faster-acting medication with fewer visual side effects. It’s available in Valif 20mg oral tablets, a trusted option in the Australian market.
As noted by WebMD, Vardenafil tends to act more quickly than Sildenafil, though both deliver similar effectiveness when used correctly.
How Do They Work in the Body?
Both drugs target the same enzyme — phosphodiesterase type 5 (PDE5) — responsible for controlling blood flow in penile tissue.
When sexually stimulated, nitric oxide is released, which increases cyclic GMP, leading to smooth muscle relaxation and stronger blood flow. Sildenafil and Vardenafil both enhance this natural process.
The key difference:
Vardenafil has a stronger binding affinity to PDE5, which can make it act slightly faster.
Sildenafil may take longer but offers more consistent duration.
Related reading: Explore Sildenafil 50mg vs 100mg vs 200mg to understand dosage impact.
Speed and Duration: Which Works Faster?
| Feature | Sildenafil (Cenforce) | Vardenafil (Valif) |
|---|---|---|
| Onset Time | 30–60 minutes | 20–45 minutes |
| Peak Effect | Around 1 hour | Around 45 minutes |
| Duration | 4–6 hours | 4–5 hours |
| Best Taken | On empty stomach | On empty stomach |
| Alcohol Interaction | Moderate sensitivity | Slightly more tolerant |
In practical use, Vardenafil starts working faster, while Sildenafil lasts longer.
If you want a medication with rapid onset for spontaneous situations, Valif may be ideal.
If you prefer longer-lasting effects, Cenforce provides greater flexibility.
Side Effects and Safety
Both medications are well-tolerated when used properly.
Typical side effects include mild headache, flushing, nasal congestion, or dizziness.
However, subtle differences exist:
- Sildenafil: More likely to cause visual disturbances (temporary blue tint).
- Vardenafil: May cause less flushing and fewer vision changes.
Important: Do not combine either with nitrates or heavy alcohol consumption. See Common Side Effects of ED Medications for safe-use advice.
The Therapeutic Goods Administration (TGA) advises men to use PDE5 inhibitors only under medical supervision.
Price and Availability in Australia
| Medication | Availability | Price Range (AUD) | Notes |
|---|---|---|---|
| Cenforce (Sildenafil) | Widely available | $2–$4 per tablet | Affordable, various strengths |
| Valif (Vardenafil) | Limited stock | $4–$6 per tablet | Premium option, faster onset |
CenforceAU offers both Cenforce 200mg and Valif 20mg with discreet Australia-wide delivery and secure checkout.
As of 2025, Cenforce remains one of the best-value Sildenafil options in Australia, trusted for consistency and safety.
Doctor’s Recommendation: When to Choose Which
| Situation | Recommended Option | Why |
|---|---|---|
| Need fast onset | Vardenafil (Valif) | Works within 20–30 minutes |
| Want longer duration | Sildenafil (Cenforce) | Lasts up to 6 hours |
| Sensitive to visual side effects | Vardenafil | Lower risk |
| Seeking affordable daily option | Sildenafil | Budget-friendly |
| Trying ED meds for the first time | Sildenafil | Widely researched and proven |
Doctors often recommend starting with Sildenafil due to its availability and clinical data.
If you experience mild side effects or need quicker results, Vardenafil can be a suitable alternative.
Lifestyle and Absorption Tips
Both drugs work best under similar conditions:
- Take on an empty stomach or after a light meal.
- Avoid heavy alcohol before use.
- Stay hydrated and reduce stress.
You can read more in How Food, Alcohol, and Lifestyle Affect Sildenafil Effectiveness for science-backed optimisation tips.
Conclusion: Similar Purpose, Slightly Different Experience
In summary, Sildenafil and Vardenafil share the same mechanism, but they differ slightly in onset speed and duration. Vardenafil acts faster, while Sildenafil lasts longer and costs less.
Both are effective, safe, and approved under Australian standards when purchased through reliable suppliers like CenforceAU — your trusted source for genuine ED medications and discreet home delivery.
FAQ
Q: Which is safer, Sildenafil or Vardenafil?
Both are equally safe when prescribed. Consult your doctor if you have heart or liver conditions.
Q: Can I take Vardenafil after Sildenafil?
No. Never mix PDE5 inhibitors. Wait at least 24 hours between doses.
Q: Does food affect both medications the same way?
Yes, fatty meals delay absorption for both. Take on an empty stomach for faster results.
Q: Which one is better for older men?
Vardenafil may be preferred for its lower blood pressure impact, but always check with a doctor first.